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At NeuroLab we make use of neuroimaging, genetic, behavioral and neuropsychological approaches to investigate the cognitive skills and neural mechanisms underlying the human ability to orient and navigate in spatial surroundings. We are interested in understanding the fundamental mechanisms related to spatial cognition throughout the life span (from early development to the elderly) and in the event of clinical conditions affecting the central nervous system. We have many projects that may interest you. Explore our website to find out more about our research!


------------------------------------------ OUR MOST RECENT PUBLICATION ------------------------------------------

FAMILIAL AGGREGATION IN DEVELOPMENTAL TOPOGRAPHICAL DISORIENTATION (DTD)
Barclay, S. F., Burles, F., Potocki, K., Rancourt, K. M., Nicolson, M. L., Bech-Hansen, T. N., Iaria, G. (2016). Cognitive Neuropsychology, Dec 6:1-10. [Epub ahead of print].

A variety of brain lesions may affect the ability to orient, resulting in what is termed “acquired topographical disorientation”. In some individuals, however, topographical disorientation is present from childhood, with no apparent brain abnormalities and otherwise intact general cognitive abilities, a condition referred to as “developmental topographical disorientation” (DTD). Individuals affected by DTD often report relatives experiencing the same lifelong orientation difficulties. Here, we sought to assess the familial aggregation of DTD by investigating its occurrence in the families of DTD probands, and in the families of control probands who did not experience topographical disorientation. We found that DTD appears to cluster in the DTD families, with tested relatives displaying the trait, whereas in the control families we did not detect any individuals with DTD. These findings provide the very first evidence for the familial clustering of DTD and motivate further work investigating the genetic factors producing this clustering.

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